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Ultracentrifuge
The ultracentrifuge is a centrifuge optimized for spinning a rotor at very high speeds, capable of generating acceleration as high as (approx. ). There are two kinds of ultracentrifuges, the preparative and the analytical ultracentrifuge. Both classes of instruments find important uses in molecular biology, biochemistry, and polymer science.〔Susan R. Mikkelsen & Eduardo Cortón. Bioanalytical Chemistry, Ch. 13. Centrifugation Methods. John Wiley & Sons, Mar 4, 2004, pp. 247-267.〕
==History==
Theodor Svedberg invented the analytical ultracentrifuge in 1925,〔(【引用サイトリンク】title= Svedberg )〕〔Joe Rosen; Lisa Quinn Gothard. ''(Encyclopedia of Physical Science )''. Infobase Publishing; 2009. ISBN 978-0-8160-7011-4. p. 77.〕 and won the Nobel Prize in Chemistry in 1926 for his research on colloids and proteins using the ultracentrifuge.
The vacuum ultracentrifuge was invented by Jesse W. Beams in the Physics Department at the University of Virginia. It was his contribution of the vacuum which allowed a reduction in friction generated at high speeds. Vacuum systems also enabled the maintenance of constant temperature across the sample, eliminating convection currents that interfered with the interpretation of sedimentation results. 〔Elzen B. ''Vacuum ultracentrifuge.'' In: Encyclopedia of 20th-Century Technology, Colin Hempstead & William Worthington, eds. Routledge, 2005. p. 868.〕
In 1946, Pickels cofounded Spinco (Specialized Instruments Corp.) to market analytical and preparative ultracentrifuges based on his design. Pickels considered his design to be too complicated for commercial use and developed a more easily operated, “foolproof” version. But even with the enhanced design, sales of analytical centrifuges remained low, and Spinco almost went bankrupt. The company survived by concentrating on sales of preparative ultracentrifuge models, which were becoming popular as workhorses in biomedical laboratories.〔 In 1949, Spinco introduced the Model L, the first preparative ultracentrifuge to reach a maximum speed of 40,000 rpm. In 1954, Beckman Instruments, now Beckman Coulter, purchased the company, forming the basis of its Spinco centrifuge division.〔Arnold O. Beckman: One Hundred Years of Excellence. By Arnold Thackray and Minor Myers, Jr. Philadelphia: Chemical Heritage Foundation, 2000.〕
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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